Bring a large pot of salted water to a boil. Add the penne pasta and cook until al dente according to package instructions. Drain and set aside.
8 ounces penne pasta
Heat olive oil in a skillet over medium-high heat. Add ground beef and cook, breaking apart with a spatula, until browned and cooked through, about 6-8 minutes. Drain excess fat.
1 pound ground beef
Add cumin, chili powder, salt, and pepper to the beef. Stir well and cook for 1-2 minutes until fragrant.
1 teaspoon cumin, 1 teaspoon chili powder
Combine cooked pasta and seasoned beef in the skillet with salsa. Mix thoroughly until evenly coated and heated through, about 2-3 minutes.
8 ounces penne pasta, 1 pound ground beef, 1 cup salsa
Transfer the mixture to a greased baking dish. Sprinkle shredded cheese evenly over the top.
1 cup salsa, 1 cup shredded cheese
Bake in a preheated oven at 375°F (190°C) for 15-20 minutes, or until bubbly and the cheese is melted and golden brown. Remove from oven and let sit for 5 minutes before serving.